Which medication used to treat hyperaldosteronism may cause menstrual disorders in women?

• A. Spironolactone
• B. Amlodipine
• C. Dexamethasone
• D. Aminoglutethimide

Answer: (A)

Spironolactone blocks the effect of aldosterone in the kidneys, which helps treat hyperaldosteronism by promoting potassium retention and water excretion. In women, its antiandrogenic effects can disrupt normal ovulatory cycles, leading to menstrual irregularities or amenorrhea. This side effect is a well-recognized consequence of spironolactone’s hormonal actions, making it the medication linked to menstrual disturbances among those listed. The other drugs don’t target aldosterone receptors in the same way and aren’t used as first-line treatments for hyperaldosteronism, so they’re not associated with this specific menstrual effect.