Glucocorticoids may cause which metabolic effect requiring monitoring?

• A. Hypoglycemia
• B. Increased urine output
• C. Hypotension
• D. Hyperglycemia

Answer: (D)

Glucocorticoids raise blood glucose by stimulating liver gluconeogenesis and reducing peripheral glucose uptake, which leads to hyperglycemia. This metabolic effect requires monitoring of blood glucose, especially in patients with diabetes or those at risk for glucose intolerance. While these drugs can cause other fluid-related or pressure changes in some individuals, the most important and consistent metabolic concern is elevated glucose levels.