Aminoglutethimide is used to treat Cushing's syndrome. Which option correctly identifies this use?

• A. Thyroid cancer
• B. Adrenal cancer
• C. Testicular cancer
• D. Cushing's syndrome

Answer: (D)

Aminoglutethimide treats Cushing's syndrome by lowering cortisol production from the adrenal glands. It blocks the first step in adrenal steroid synthesis—the enzyme that converts cholesterol to pregnenolone—so less cortisol (and other adrenal steroids) are made. With cortisol levels reduced, the signs and symptoms of hypercortisolism improve. This use fits the problem of excessive cortisol, rather than addressing thyroid, testicular, or adrenal tumors directly, which is why those other options aren’t correct. In practice, it’s considered when surgery isn’t possible or as part of a medical therapy plan, with attention to potential hormonal and metabolic side effects.